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Topical Magnesium: What Science Tells Us

Topical Magnesium: What Science Tells Us

This is one of our favorite topics here at Dryft Sleep because research is front and center to the discussion. 

The Facts: Magnesium is a critical mineral for muscle relaxation, nerve function, and sleep quality. We love magnesium for its natural ability to esae muscles and put us into a relaxing state before bed. We want to break down the research here to share peer-reviewed research about topical versus ingested magnesium, the safest forms to use, and how these choices may help your nightly sleep rituals. Let's dive in! 

Topical vs. Ingested Magnesium: The Evidence

Oral magnesium supplements (tablets, powders, capsules) remain the gold standard for correcting magnesium deficiency, supported by decades of clinical research. Oral supplementation is shown to be effective in treating low magnesium linked to cardiovascular disease, diabetes, osteoporosis, and migraines.

Topical magnesium, such as creams, sprays, or bath salts, is promoted as bypassing the digestive tract for fewer side effects. However, reviews from medical journals point out that concrete scientific evidence around transdermal (skin) absorption remains limited and, at times, inconclusive. Pilot trials show transdermal absorption is possible and can increase serum magnesium in some subgroups, but more research is needed to determine if this is reliable and clinically significant for most people.

Types of Magnesium: Safe Options Backed by Medical Research

Magnesium comes in multiple forms, not all equally effective or suitable:

Magnesium Type Route Main Use Research Notes
Magnesium Glycinate Oral Gentle, sleep/calming, muscle recovery Highly bioavailable, fewer GI side effects
Magnesium Citrate Oral Constipation, absorption Well-absorbed, mild laxative
Magnesium Oxide Oral Less expensive, GI complaints Low absorption, more side effects
Magnesium Chloride Both Topical (creams, sprays); also oral forms Used in most topical studies (this is what's in Dryft Sleep's Magnesium Sleep Spray)
Magnesium Sulfate Topical Bath soaks (Epsom salts), muscle relaxation Used for relaxation, not for correcting deficiency

Safety Note: Always consult a healthcare provider, especially if you have kidney disease, other chronic conditions, or take multiple medications, before supplementing.

Who May Benefit Most from Topical Magnesium?

Scientific studies suggest that certain groups could find topical magnesium especially useful:

  • People with gastrointestinal sensitivity: Those who experience digestive side effects from oral magnesium may tolerate skin applications better.
  • Athletes or those with muscle cramps: Local application may help muscle tension, though more high-quality studies are needed.
  • Peripheral neuropathy sufferers: Recent pilot research in chronic kidney disease patients found that daily topical magnesium chloride sprays may reduce neuropathy symptoms, though serum magnesium didn’t increase significantly.
  • Chronic pain: Some studies hint at benefits for certain chronic pain or fibromyalgia patients, but support is not yet robust.

Magnesium and Sleep: What Does the Research Say?

A number of clinical and observational studies associate magnesium with sleep regulation, sleep onset, and maintenance. Magnesium is involved in neurotransmitter regulation vital for healthy sleep patterns. Systematic reviews and clinical trials indicate that:

  • Low magnesium is linked to poor sleep quality.
  • Magnesium supplementation (mainly oral) can improve insomnia outcomes, especially in older adults.
  • The evidence for topical magnesium improving sleep is promising but not yet definite, and further controlled trials are recommended.
  • The ritual of applying topical magnesium (like massage or a bath), regardless of absorption, may itself become a relaxing trigger that contributes to better sleep hygiene.

Science-Driven Recommendations from Dryft Sleep

  • For magnesium deficiency: Oral supplementation remains the most proven route.
  • If digestive issues exist: Consider trialing reputable topical magnesium, understanding scientific support is still emerging.
  • For sleep rituals: Products like magnesium bath salts or creams may aid relaxation and become part of a soothing bedtime routine.
  • Always check with your provider for personal guidance, especially with existing health conditions.

While oral magnesium has the strongest scientific backing for correcting deficiency and supporting sleep, topical magnesium may be a gentle option for those with GI problems and for enhancing bedtime relaxation. The science behind transdermal absorption is still developing, so results may vary. Keep an open dialogue with your healthcare provider to craft the best sleep-supportive regimen for your needs.

Ready to try magnesium for your sleep. Check out our offerings here

Sleep well,
The Sleep Experts at Dryft Sleep

Citations for the research above: 
  1. Gröber U, Schmidt J, Kisters K. "Magnesium in Prevention and Therapy." Nutrients, 2015.
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586582/
  2. Razzaque MS. "Magnesium: Are We Consuming Enough?" Nutrients, 2018.
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315556/
  3. Schuchardt JP, Hahn A. "Intestinal Absorption and Factors Influencing Bioavailability of Magnesium—An Update." Current Nutrition & Food Science, 2017.
    https://www.eurekaselect.com/150836/article
  4. Barbagallo M, Dominguez LJ. "Magnesium and aging." Current Pharmaceutical Design, 2010.
    https://pubmed.ncbi.nlm.nih.gov/20298174/
  5. Gröber U, Werner T, Vormann J, Kisters K. "Myths and realities regarding oral supplementation with magnesium: A review." European Journal of Clinical Nutrition, 2017.
    https://pubmed.ncbi.nlm.nih.gov/28248258/
  6. Whelan AM, Jurgens TM, Bowtell JL. "Transdermal Magnesium: A Pilot Study to Assess the Efficacy of Topical Magnesium in Lowering Blood Pressure in Hypertensive Subjects." Integrative Medicine (Encinitas), 2016.
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5671399/
  7. Walker AF, Marakis G, Christie S, Byng M, Simpson HC. "MgCl₂ (topical magnesium chloride) absorption study." Nutritional Practitioner, 2018.
  8. Garrison SR, Allan GM, Sekhon RK, Musini VM. "Magnesium for skeletal muscle cramps." Cochrane Database Syst Rev, 2012.
    https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD009402/full
  9. Rondon-Berrios H, Berl T. "Chronic kidney disease and metabolic acidosis." Current Opinion in Nephrology and Hypertension, 2010.
    https://journals.lww.com/co-nephrolhypertens/Abstract/2010/07000/Chronic_kidney_disease_and_metabolic_acidosis.13.aspx
  10. Abbasi B et al. "The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial." Journal of Research in Medical Sciences, 2012.
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703169/
  11. Rondanelli M et al. "Effects of melatonin, magnesium, and zinc on primary insomnia in long-term care facility residents in Italy: a double-blind, placebo-controlled clinical trial." Journal of the American Geriatrics Society, 2011.
    https://agsjournals.onlinelibrary.wiley.com/doi/full/10.1111/j.1532-5415.2010.03242.x
  12. Institute of Medicine (US) Standing Committee on the Scientific Evaluation of Dietary Reference Intakes. "Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride." National Academies Press (US), 1997.
    https://www.ncbi.nlm.nih.gov/books/NBK109825/
  13. National Institutes of Health, Office of Dietary Supplements. "Magnesium Fact Sheet for Health Professionals."
    https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/
  14. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA). "Scientific opinion on the substantiation of health claims related to magnesium." EFSA Journal, 2015.
    https://efsa.onlinelibrary.wiley.com/doi/10.2903/j.efsa.2011.2171

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